4.7 Article

Catalytic decarboxylative alkylation of beta-keto acids with sulfonamides via the cleavage of carbon-nitrogen and carbon-carbon bonds

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 29, Pages 8343-8345

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12790j

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Funding

  1. National Natural Science Foundation of China [20972147, 20732006]
  2. National Basic Research Program of China [2010CB833300]
  3. Chinese Academy of Sciences

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An efficient decarboxylative alkylation reaction of beta-keto acids with N-benzylic or N-allylic sulfonamides has been developed, for the first time, through sequential cleavage of carbon-nitrogen and carbon-carbon bonds in the presence of 10 mol% of FeCl(3).

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