4.7 Article

Triggered activity of a nicking endonuclease for mercuric(II) ion-mediated duplex-like DNA cleavage

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 22, Pages 6347-6349

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11858g

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Funding

  1. National Basic Research Program of China (973 Program) [2007CB936000]
  2. National Natural Science Funds for Distinguished Young Scholars [20725518]
  3. National Natural Science Foundation of China [90713019, 20875058, 20775039]

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The cleavage activity of a nicking endonuclease towards metal-ion-mediated duplex-like DNA can be triggered by the corresponding metal ions, which was demonstrated with mercuric(II) ion as a model via a simple electrochemical protocol.

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