4.7 Article

Label-free fluorescent detection of Cu(II) ions based on DNA cleavage-dependent graphene-quenched DNAzymes

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 27, Pages 7749-7751

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12006a

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Funding

  1. National Basic Research Program of China [2011CB936002]
  2. Fundamental Research Funds for the Central Universities [DUT 10ZD115]
  3. Program for Changjiang Scholars and Innovative Research Team in University [IRT0813]

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We developed a novel and general methodology to design a label-free fluorescent Cu(II) sensor based on internal DNA cleavage and an extrinsic fluorophore in a graphene/DNAzymes complex with high sensitivity and selectivity.

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