4.7 Article

Human telomeric G-quadruplexes undergo dynamic conversion in a molecular crowding environment

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 12, Pages 3517-3519

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc05242f

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Funding

  1. National Science Foundation of China [90813031, 30973605, 20921062, 21072155]
  2. National Key Foundation for Infectious Diseases [2008ZX10003-005]
  3. Fundamental Research Funds for the Central Universities

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We provide a novel insight into dynamic conversion of the human telomeric G-quadruplexes and particularly a step-to-step transformation pathway of the long sequence containing two quadruplex units in K+ solution in a molecular crowding environment, implying a possible behavior of the human telomeric DNA under physiological conditions.

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