4.7 Article

Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 13, Pages 3897-3899

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc05840h

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An amino-indanol derived chiral guanidine was developed as an efficient Bronsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities.

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