4.7 Article

Concise synthesis of catechin probes enabling analysis and imaging of EGCg

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 6, Pages 1794-1796

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc03676e

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Funding

  1. Shizuoka Prefecture and Shizuoka City Collaboration of Regional Entities for the Advancement of Technological Excellence
  2. Japan Science and Technology Agency (JST)
  3. Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
  4. Grants-in-Aid for Scientific Research [23590006] Funding Source: KAKEN

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A concise synthesis of APDOEGCg (3) was accomplished. Due to the reactivity of its amine group, the compound could be easily converted to the fluorescein probe 21 and immunogen probe 22 efficiently. We then demonstrated the usefulness of the probes for imaging studies and the generation of antibodies.

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