4.7 Article

Synthesis of a MUC1-glycopeptide-BSA conjugate vaccine bearing the 3 '-deoxy-3 '-fluoro-Thomsen-Friedenreich antigen

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 35, Pages 9903-9905

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13184b

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A novel MUC1-glycopeptide-BSA conjugate vaccine with a specifically fluorinated Thomsen-Friedenreich antigen side chain at Thr6 was prepared. Preliminary immunological experiments reveal specific binding of the tumor-associated glycopeptide antigen analog by anti-MUC1-mouse antibodies.

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