4.7 Article

A near-infrared fluorescent probe for detecting copper(II) with high selectivity and sensitivity and its biological imaging applications

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 27, Pages 7755-7757

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11885d

Keywords

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Funding

  1. National Basic Research Program of China (973 Program) [2007CB936000]
  2. National Natural Science Funds for Distinguished Young Scholar [20725518]
  3. National Key Natural Science Foundation of China [21035003]
  4. National Natural Science Foundation of China [20975063]
  5. Science and Technology Development Programs of Shandong Province of China [2008GG30003012]
  6. Key Natural Science Foundation of Shandong Province of China [ZR2010BZ001]
  7. Scientific and technological projects in Shandong Province [2010G0020243]

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The first near-infrared fluorescent probe was developed toward Cu2+. Based on the photo-induced electron transfer (PET) mechanism, the probe exhibited weak fluorescence. Upon the addition of Cu2+, it fluoresced strongly. The probe offered this unique capability, and was successfully applied to living cells, tissues and in vivo to visualize Cu2+.

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