4.7 Article

Fluorescent trimethyl-substituted naphthyridine as a ligand for C-C mismatch detection in CCG trinucleotide repeats

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 20, Pages 5885-5887

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11370d

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan [20350032]
  2. JSPS
  3. Grants-in-Aid for Scientific Research [22225003] Funding Source: KAKEN

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We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C-C mismatch present in the hairpin structures of (CCG)(n) trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.

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