Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 46, Pages 12453-12455Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc15557a
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- Ministry of Education, Culture, Sports, Science and Technology of Japan [21221009, 20611006]
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Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 induced apoptosis in HL60 human leukemia cells.
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