4.7 Article

Exo-Cyclopamine-a stable and potent inhibitor of hedgehog-signaling

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 26, Pages 7362-7364

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11782c

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The combination of theoretical and computational studies with organic synthesis and biological investigations has led to exo-cyclopamine. This stable and highly potent derivative of cyclopamine promises big potential as an experimental drug against several types of human cancer.

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