4.7 Article

Unexpected phosphodiesterase activity at low pH of a dinuclear copper-beta-cyclodextrin complex

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 26, Pages 7344-7346

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12466h

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Funding

  1. National Natural Science Foundation of China [30770494, 20725103, 20831006, 20821001]
  2. Guangdong Provincial Natural Science Foundation [9351027501000003]
  3. National Basic Research Program of China (973 Program) [2007CB815306]
  4. Fundamental Research Funds for the Central Universities

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A surprisingly low pK(a) (4.3) for a Cu(II) bridging water was found in the presented complex, Cu2L, resulting in 3 orders of magnitude higher phosphodiesterase activity on BNPP than Zn2L at typical lysosomal pH (similar to 5.0).

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