4.7 Article

Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 23, Pages 6575-6577

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc11356a

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Funding

  1. EU RTN network [MARCY RTN HPRN-CT-2002-00175]
  2. University of Birmingham
  3. EU [MEST-CT-2005-020842]
  4. Frontier Research Networks of the Commission on Higher Education, Government of Thailand
  5. NMR equipment

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The conjugation of arginine residues at the ends of a metallo-supramolecular triple-helical cylinder enables absolute control over the helicity of the cylinder core, and boosts the DNA junction recognition by the complexes and their activity against a cancer cell line.

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