Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 21, Pages 5997-5999Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc05605g
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Funding
- NWO [700.56.428]
- Spanish Ministry of Education [BFU2010-17824]
- European Union [EU-CP223111]
- BSIK program Molecular Imaging of Ischemic Heart Disease [BSIK03033]
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A modular self-assembly strategy is presented that allows the non-covalent synthesis of multivalent protein dendrimers using the strong interaction between choline-functionalized dendrimers and the choline binding protein C-LytA. Choline dendrimers displaying fusion proteins of C-LytA and the collagen binding protein CNA35 represent attractive multivalent targeting ligands for collagen imaging.
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