Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 36, Pages 10010-10012Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13524d
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Funding
- European Commission
- FCT Portugal
- International AIDS Vaccine Initiative
- Royal Society of Chemistry
- Bill and Melinda Gates Fundation
- Royal Society
- EPSRC
- Biotechnology and Biological Sciences Research Council [BB/E004350/1, BB/C510824/1, EGA17763] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/D023335/1, EP/I500200/1, EP/E000614/1, GR/T26542/01, EP/G026688/1, EP/D023343/1] Funding Source: researchfish
- BBSRC [BB/E004350/1] Funding Source: UKRI
- EPSRC [EP/I500200/1, EP/G026688/1, EP/E000614/1] Funding Source: UKRI
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A strategy for the site-specific attachment of 2-deoxy-2-fluorosugars to cysteine and dehydroalanine tagged proteins is reported. When combined with thionation of fluorosugars, such as the widely available F-18 probe 2-deoxy-2-[F-18]fluoroglucose ([F-18]FDG), this methodology allows fast and direct access to site-specific [F-18]FDG-labelled proteins.
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