Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 38, Pages 10605-10607Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13949e
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Funding
- EPSRC
- The University of Nottingham
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A synthetic approach towards the structurally complex dimer, kingianin A is reported. The strategy involved a cascade of complexity generating reactions, inspired through biosynthetic speculation. A concise protecting group free synthesis of the proposed monomeric precursor pre-kingianin A has been achieved using a tandem Stille cross-coupling reaction and electrocyclisation process. However, preliminary studies of the key dimerisation reaction have been conducted, which indicate that the process is not spontaneous, raising questions as to the origin of this complex natural product.
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