4.7 Article

A sensitive and selective resonance light scattering bioassay for homocysteine in biological fluids based on target-involved assembly of polyethyleneimine-capped Ag-nanoclusters

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 13, Pages 3817-3819

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc04463f

Keywords

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Funding

  1. National Natural Science Foundation of China [20935001, 20977049, 21077057]
  2. National Basic Research Program of China [2011CB707703]
  3. Tianjin Natural Science Foundation [10JCZDJC16300, 09JCYBJC03900]

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A specific resonance light scattering bioassay for homocysteine is developed on the basis of target-involved assembly of polyethyleneimine-capped Ag-nanoclusters. The bioassay permits discriminating homocysteine from cysteine, glutathione and other amino acids, and allows sensitive and selective detection of homocysteine with a detection limit of 42 nM.

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