4.7 Article

A graphene oxide-peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 38, Pages 10680-10682

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13975d

Keywords

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Funding

  1. National Basic Research Program of China [2011CB935800, 2010CB933502]
  2. NSF of China [20935005, 90813032, 20905070]
  3. Chinese Academy of Science [KJCX2-EW-N06-01]

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A graphene oxide-peptide based fluorescence sensor has been developed for matrix metalloproteinase 2 (MMP2), and its applicability has been demonstrated by monitoring the concentration of MMP2 secreted by HeLa cells, revealing that HeLa cells with a density of 5.48 x 10(5) cells per mL can produce 22 nM in cell culture media in 24 h.

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