Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 14, Pages 4162-4164Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc00078k
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22000006, 20689001, 21659204]
- Industrial Technology Development Organization (NEDO) of Japan
- Research Foundation for Pharmaceutical Sciences
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We present a design strategy for fluorescence probes with a high off/on activation ratio in the red wavelength region, based on a novel fluorescein analogue in which the O atom at the 10 position of the xanthene chromophore is replaced with a Si atom. To demonstrate the usefulness of this strategy, we designed and synthesized a red-fluorescent probe for beta-galactosidase, and showed that it works in live HEK293 cells.
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