4.7 Article

Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 30, Pages 8647-8649

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc12495a

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Funding

  1. National Natural Science Foundation of China [21004045]
  2. Shanghai Natural Science Foundation [10ZR1432100]
  3. Northwest University [10YSY09]
  4. Important Projects in Science and Technology Innovation of Shaanxi [2008ZDKG-58]

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A novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed.

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