4.7 Article

Bio-functionalization of metal-organic frameworks by covalent protein conjugation

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 10, Pages 2904-2906

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc03288c

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Funding

  1. Ministry of Education, Science and Technology (MEST) [NRF-2007-331-C00170]

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Bioconjugation of functional proteins onto metal-organic frameworks (MOFs) has been achieved using activation of pendent linking groups of the organic linkers on the surface of MOFs. Fluorescent microscopy revealed successful conjugation of an enhanced fluorescent protein onto MOFs. In addition, Candida-antarctica-lipase-B-conjugated MOFs showed no loss of enantioselectivity and activity in transesterification of (+/-)-1-phenylethanol.

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