4.7 Article

SiO2@Fe2O3 core-shell nanoparticles for covalent immobilization and release of sparfloxacin drug

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 36, Pages 10076-10078

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13708e

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Funding

  1. University of Cologne
  2. Alexander von Humboldt Foundation
  3. European Commission [214281]

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Silica-coated Fe2O3 nanoparticles were synthesized as carriers for the covalent immobilization and release of antimicrobial drug sparfloxacin (SPFX). SPFX-loaded nanoparticles exhibited time-dependent drug release, with no measurable in vitro cytotoxicity, making the drug@nanoparticle conjugates potentially relevant for nanomedicine applications.

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