Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 37, Pages 10335-10337Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13341a
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- R.S. Goody
- International Max Planck Research School in Chemical Biology
- Alfred P. Sloan Fellowship
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We have developed a synthesis of phosphoarginine containing peptides using a bis(2,2,2-trichloroethyl) protected phosphoarginine derivative as building block. Binding studies and computer modelling demonstrate the ability of the SH2 domain from Src kinase to recognize a phosphoarginine-containing peptide in a phosphoryl group-dependent manner.
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