Journal
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
Volume 64, Issue 1, Pages 34-+Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MMBR.64.1.34-50.2000
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Comprehensive knowledge regarding Saccharomyces cerevisiae has accumulated over time, and today S. cerevisiae serves as a widley used biotechnological production organism as well as a eukaryotic model system. The high transformation efficiency, in addition to the availability of the the complete yeast genome sequence has facilitated genetic manipulation of this microorganism, and new approaches are constantly being taken to metabolicially engineer this organism in oder to suit specific needs. In this paper; strategies and concepts for metabolic engineering are discussed and several examples based upon selected studies involving S, cerevisiae are reviewed. The many different studies of metabolic engineering using this organism illustrate all the categories of this multidisciplinary field: extension of substrate range, improvements of producitivity and yield, elimination of byproduct formation, improvement of process performance, improvements of cellular properties, and extension of product range including heterologous protein production.
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