4.7 Article

High precision NOEs as a probe for low level conformers-a second conformation of strychnine

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 4, Pages 1193-1195

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc04114a

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Funding

  1. University of Bristol
  2. EPSRC [EP/F013515/1]
  3. BBSRC [BB/F011539/1]
  4. Biotechnology and Biological Sciences Research Council [BB/F011539/1] Funding Source: researchfish
  5. Engineering and Physical Sciences Research Council [EP/F013515/1] Funding Source: researchfish

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A second conformer of strychnine, with a very low population (2.5%), has been identified experimentally, and confirmed by computation, demonstrating the ability of NOE measurements to discriminate minute contributions to dynamic structure ensembles in solution.

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