Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 12, Pages 3418-3420Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc04916f
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- Syracuse University
- Syracuse Biomaterials Institute (SBI)
- AFOSR
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The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.
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