4.7 Article

Mechanism of glutaredoxin-ISU [2Fe-2S] cluster exchange

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 17, Pages 4989-4991

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc05079b

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Funding

  1. National Institutes of Health [AI072443]
  2. Grants-in-Aid for Scientific Research [15K10899] Funding Source: KAKEN
  3. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI072443] Funding Source: NIH RePORTER

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Exchange of [2Fe-2S] centers between Grx2 and the cluster scaffold protein ISU, and characterization of two mutually exclusive Grx2 binding sites on ISU by isothermal titration calorimetry supports a direct link for Grx and glutathione involvement in ISU promoted Fe-S cluster biosynthesis.

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