Journal
ACTA CLINICA BELGICA
Volume 55, Issue 2, Pages 79-87Publisher
ACTA CLINICA BELGICA
DOI: 10.1080/17843286.2000.11754275
Keywords
cytokines; inflammatory response; nitric oxide
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Sepsis results from the activation of a complex cascade of mediators, an appropriate and necessary body response to infection or insult which can, however, become excessive and detrimental to the host. When the immunological host response is not well controlled, it may lead to multiple organ failure and death. This manuscript reviews the epidemiology and the major factors involved in the development of sepsis, and considers a number of therapeutic interventions that may help to better control the septic process and the related development of multiple organ failure.
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