4.7 Article

Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 30, Pages 5569-5571

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc00050g

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Funding

  1. VINNOVA (The Swedish Governmental Agency for Innovation Systems)
  2. COST [CM0701]

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Enantiopure chiral amines synthesis using omega-transaminases is hindered by an unfavourable equilibrium, but when using isopropylamine as the amine donor the equilibrium can be completely displaced by using a specific dehydrogenase in situ for removal of formed acetone.

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