Journal
ANNUAL REVIEW OF PHYSIOLOGY
Volume 62, Issue -, Pages 535-572Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.62.1.535
Keywords
CFTR; secretagogues; fluid and electrolyte transport; growth factors; membrane transporters
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Funding
- NIDDK NIH HHS [DK53480, DK35108, DK28305] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK053480, R01DK028305, P01DK035108] Funding Source: NIH RePORTER
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Chloride secretion is the major determinant of mucosal hydration thoughout the gastrointestinal tract, and chloride transport is also pivotal in the regulation of fluid secretion by organs that drain into the intestine. Moreover, there are pathological consequences if chloride secretion is either reduced or increased such as in cystic fibrosis and secretory diarrhea, respectively. With the molecular cloning of many of the proteins and regulatory factors that make up the chloride secretory mechanism, there have been significant advances in our understanding of this process at the cellular level. Similarly, emerging data have clarified the intercellular relationships that govern the extent of chloride secretion. The goal of our article is to review this area of investigation, with an emphasis on recent developments and their implications for the physiology and pathophysiology of chloride transport.
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