4.7 Article

One pot 'click' reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 6, Pages 898-900

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b919434g

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Funding

  1. Netherlands Ministry of Economic Affairs
  2. B-Basic partner organizations, a public-private NWO-ACTS
  3. University Medical Center Groningen

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Halohydrin dehalogenase (HheC) can perform enantioselective azidolysis of aromatic epoxides to 1,2-azido alcohols which are subsequently ligated to alkynes producing chiral hydroxy triazoles in a one-pot procedure with excellent enantiomeric excess.

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