4.7 Article

Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 17, Pages 3004-3006

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b922120d

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Funding

  1. National Basic Research Program of China [2010CB923303]
  2. National Science Foundation of China (NSFC) [20902045]
  3. National Institutes of Health [R01GM069990]
  4. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069990] Funding Source: NIH RePORTER

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Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.

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