4.7 Article

Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 41, Pages 7688-7690

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc01782e

Keywords

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Funding

  1. NSFC [20805057, 20675084, 20877091]
  2. National Basic Program of China [2010CB933502, 2009CB421605]
  3. National High Technology Research and Development Program of China [2007AA06A407]

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Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release are fabricated by the combination of template synthesis and ATRP grafting. The release of R-propranolol from the imprinted nanotubes in rats is restricted while the release of pharmacologically active S-enantiomer is greatly promoted.

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