4.7 Article

Specific derivatization of lysozyme in aqueous solution with Re(CO)(3)(H2O)(3)(+)

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 8, Pages 1203-1205

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b923688k

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Funding

  1. National Institutes of Health [R15 GM 083322]
  2. Research Corporation [CC6663/6616]
  3. National Science Foundation [CHE-0819686]
  4. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R15GM083322] Funding Source: NIH RePORTER

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The reaction of Re(CO)(3)(H2O)(3)(+) with hen egg lysozyme in aqueous solution results in a single covalent adduct; single crystal X-ray diffraction shows that the rhenium tricarbonyl cation binds to His15 in two significantly populated rotamer conformations.

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