Journal
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Volume 5, Issue 1, Pages 85-94Publisher
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/A:1009571417429
Keywords
mannose 6-phosphate/insulin-like growth factor 2 receptor; tumor suppressor gene; breast cancer; loss of heterozygosity; somatic mutation; microsatellite instability
Categories
Funding
- NATIONAL CANCER INSTITUTE [R29CA067302] Funding Source: NIH RePORTER
- NCI NIH HHS [R29CA67302-01] Funding Source: Medline
Ask authors/readers for more resources
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/ICF2R)(3) is considered a candidate tumor suppressor gene. This hypothesis has been provoked by the identification of loss of heterozygosity (LOH) at the M6P/IGF2R locus on chromosome 6q26 in breast and liver cancer, accompanied by point mutations in the remaining allele. Somatic mutations in coding region microsatellites have also been described in replication error positive (RER+) tumors of the gastrointestinal tract, endometrium and brain. These genetic data are compelling, but a tumor suppressor gene candidate has to meet functional as well as genetic criteria. This review weighs the evidence and discusses the observations that are necessary to promote M6P/ICF2R from candidate to bona fide tumor suppressor gene.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available