4.7 Article

Diastereoselective and enantioselective Mukaiyama aldol reactions of alpha-ketoesters using hydrogen bond catalysis

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 6, Pages 904-906

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b919929b

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Funding

  1. U.S. National Institutes of Health [R01GM069990]
  2. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069990, R56GM069990] Funding Source: NIH RePORTER

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Hydrogen bond catalyzed Mukaiyama aldol reactions of alpha-ketoesters proceed in high diastereo- and enantioselectivities, giving products possessing two chiral centers, of which one is a tertiary alcohol.

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