4.7 Article

Horseradish peroxidase-functionalized Pt hollow nanospheres and multiple redox probes as trace labels for a sensitive simultaneous multianalyte electrochemical immunoassay

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 36, Pages 6750-6752

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc01537g

Keywords

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Funding

  1. National Natural Science Foundation of China [20675064]
  2. Ministry of Education of China [708073]
  3. Natural Science Foundation of Chongqing City [CSTC-2009BA1003]
  4. High Technology Project Foundation of Southwest University [XSGX 02]
  5. State Key Laboratory of Electroanalytical Chemistry of Changchun Institute of Applied Chemistry [SKLEAC 2010009]

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A novel strategy for a simultaneous multianalyte electrochemical immunoassay is proposed using thionine-labeled anti-AFP and ferrocene-labeled anti-CEA as tracers; each biorecognition event yielded a distinct voltammetric peak, whose position and size reflected the identify and level of the corresponding antigen.

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