Journal
CHEMICAL COMMUNICATIONS
Volume 46, Issue 43, Pages 8207-8209Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02727h
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Miniprotein phage display screening yields structured peptides with high affinity for the Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically placed on the predefined miniprotein helical segment. The apamin scaffold also allows optimization of flanking amino acids to ensure an optimal ER binding affinity.
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