4.7 Article

Bio-bar-code dendrimer-like DNA as signal amplifier for cancerous cells assay using ruthenium nanoparticle-based ultrasensitive chemiluminescence detection

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 33, Pages 6093-6095

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc01409e

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Funding

  1. Excellent Young Scientists Foundation of Shandong Province [JQ200805]
  2. National Natural Science Foundation of China [20827005]
  3. National Basic Research Program of China [2010CB732404]

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Bio-bar-code dendrimer-like DNA (bbc-DL-DNA) is employed as a label for the amplification assay of cancer cells in combination with the newly explored chemiluminescence (CL) system of luminol-H(2)O(2)-Ru(3+) and specificity of structure-switching aptamers selected by cell-based SELEX.

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