4.7 Article

An enzymatic route to 5-deoxy-5-[F-18]fluoro-D-ribose, a [F-18]-fluorinated sugar for PET imaging

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 1, Pages 139-141

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b919364b

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Funding

  1. Medical Research Council [GO802567]
  2. BBSRC [BB/F007426/1]
  3. MRC [G0802567] Funding Source: UKRI
  4. Biotechnology and Biological Sciences Research Council [BB/F007426/1] Funding Source: researchfish
  5. Medical Research Council [G0802567] Funding Source: researchfish

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An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.

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