4.7 Article

O-Glycoligases, a new category of glycoside bond-forming mutant glycosidases, catalyse facile syntheses of isoprimeverosides

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 46, Pages 8725-8727

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc03168b

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Funding

  1. Natural Sciences and Engineering Research Council of Canada
  2. Korean Ministry of Science and Technology
  3. British Columbia Innovation Council
  4. Canada Research Chairs

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A mutant alpha-xylosidase that lacks its catalytic acid/base residue efficiently catalyses the synthesis of O-linked isoprimeverosides (Xyl-alpha-1,6GlcOR) in near quantitative yields.

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