4.7 Article

Directed evolution of gold nanoparticle delivery to cells

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 3, Pages 392-394

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b920865h

Keywords

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Funding

  1. National Institutes of Health [R21 CA135315, R01 EB003424]
  2. Welch Foundation [F-1654]
  3. NATIONAL CANCER INSTITUTE [R21CA135315] Funding Source: NIH RePORTER
  4. NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003424] Funding Source: NIH RePORTER

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A newly selected anti-receptor (anti-EGFR) aptamer was conjugated to gold nanoparticles via a facile hybridization method and was found to specifically and quantitatively direct the delivery of gold nanoparticles to cells expressing EGFR through receptor-mediated endocytosis.

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