Journal
CHEMICAL COMMUNICATIONS
Volume 46, Issue 35, Pages 6437-6448Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc00754d
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Funding
- National Natural Science Foundation of China [20732006]
- CAS
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The double hydrogen bonding activation of carbonyl functionality has been a general strategy for the design of amino amide organocatalysts for highly enantioselective direct aldol reactions of various ketones with aldehydes conducted in either organic solvents or aqueous media. Moreover, this concept may suggest an activation mode to create new catalysts for other related asymmetric transformations.
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