Journal
SEMINARS IN NEUROLOGY
Volume 20, Issue 3, Pages 307-322Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2000-9394
Keywords
meningitis; fungi; central nervous system infections
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Funding
- NIAID NIH HHS [AI-44975, AI-28388] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI044975, R56AI028388, R01AI028388] Funding Source: NIH RePORTER
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Fungi provide many benefits to humans. However, some of these fungi have the ability to become human pathogens. All the major fungal pathogens can produce meningitis. From the common cryptococcal meningitis to the rare fungal meningitis caused by a dimorphic or filamentous fungus, medical issues are discussed in this review on a fungus-specific basis. Both primary (Cryptococcus, Blastomyces, Histoplasma, Coccidioides, and other dimorphic fungi) and secondary (Aspergillus, Candida, and a series of molds) fungal pathogens can produce life-threatening central nervous system infections. These infections require immediate and precise diagnosis and carefully selected management strategies to optimize outcomes. In this review, we examine the epidemiology, pathogenesis, clinical manifestations, and treatment for fungal meningitis in all the major fungal groups.
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