Journal
CHEMICAL COMMUNICATIONS
Volume 46, Issue 14, Pages 2450-2452Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c001550d
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A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.
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