Journal
CHEMICAL SOCIETY REVIEWS
Volume 29, Issue 1, Pages 57-67Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/a903712h
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Marine natural products possessing guanidine functionalities display a considerable array of biological activity and not surprisingly have attracted considerable synthetic interest. This review discusses the isolation of several guanidine containing metabolites, primarily from the sponge Ptilocaulis spiculifer , but also from other marine organisms. It also explores the synthetic methodologies adopted for their preparation and speculates on the structural similarity of the metabolite ptilomycalin A to abiotic guanidine based anionic receptor molecules.
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