4.7 Article

Silver(I)-mediated highly enantioselective synthesis of axially chiral allenes under thermal and microwave-assisted conditions

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 2, Pages 213-215

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b914516h

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Funding

  1. The University of Hong Kong (University Development Fund)
  2. Hong Kong Research Grant Council (HKU) [7052/07P]
  3. University Grants Committee of the Hong Kong Special Administrative Region, China [AoE/P-10/01]

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Silver(I) salts mediated stereospecific transformation of optically active propargylamines to axially chiral allenes with excellent enantioselectivities (17 examples with 96-99% ee; one substrate with 91% ee) without subsequent racemization.

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