4.7 Article

Effect of hydrophobic interaction cooperating with double Lewis acid activation in a zinc(II) phosphodiesterase mimic

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 35, Pages 6497-6499

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc00838a

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Funding

  1. National Natural Science Foundation of China [30770494, 20725103, 20831006, 20821001]
  2. Guangdong Provincial Natural Science Foundation [9351027501000003]
  3. National Basic Research Program of China (973 Program) [2007CB815306]
  4. Fundamental Research Funds for the Central Universities

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The novel dinuclear Zn(II) complex (1) containing a beta-CD dimer could accelerate BNPP (a DNA substitute) hydrolysis more efficiently than catalyze HPNP (a RNA substitute) transesterification with different mechanisms involved; the beta-CDs played remarkably different roles.

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