Journal
CHEMICAL COMMUNICATIONS
Volume 46, Issue 42, Pages 8020-8022Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02969f
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Funding
- NIH [GM077403, GM073943]
- NSF [CHE-0548264]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM073943, R01GM077403] Funding Source: NIH RePORTER
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We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.
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