Journal
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY
Volume 163, Issue -, Pages 29-38Publisher
BLACKWELL PUBL LTD
DOI: 10.1111/1467-985X.00154
Keywords
adaptive randomization; design of clinical trials; time-varying treatments
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We propose a method for assigning treatment in clinical trials, called the 'biased coin adaptive within-subject' (BCAWS) design: during the course of follow-up, the subject's response to a treatment is used to influence the future treatment, through a 'biased coin' algorithm. This design results in treatment patterns that are closer to actual clinical practice and may be more acceptable to patients with chronic disease than the usual fixed trial regimens, which often suffer from drop-out and non-adherence. In this work, we show how to use the BCAWS design to compare treatment strategies, and we provide a simple example to illustrate the method.
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